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rna seq data  (Novogene)

 
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    Novogene rna seq data
    Rna Seq Data, supplied by Novogene, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/rna-seq+data/data+rna+seq/pm42314650-341-0-6
    Average 86 stars, based on 1 article reviews
    rna seq data - by Bioz Stars, 2026-11
    86/100 stars

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    Related Articles

    RNA Sequencing:

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) , limma (3.54.2) , and edgeR (3.40.2) ( , ) packages in R (R version 4.2.2) ( ) to identify genes differentially expressed between the High and Low miR-1 responders ( P < 0.05).

    Article Title: Trimethylamine-N-oxide enhances drought tolerance in Eucalyptus by increasing photosynthesis.
    Article Snippet: Drought stress significantly reduces agricultural productivity, threatening global food security and timber production.. Although trimethylamine-N-oxide (TMAO) has been shown to enhance drought tolerance in plants such as Arabidopsis thaliana and tomato, the physiological and molecular mechanisms by which it regulates drought tolerance in plants remain unclear.. In this study, we investigated the physiological and transcriptomic changes in Eucalyptus under drought stress following exogenous TMAO treatment.

    Article Title: Improving gene isoform quantification with miniQuant.
    Article Snippet: Paired-end Illumina RNA-seq data (2 × 150 bp) were generated in Novogene company, with three replicates for each of four samples (ESC, DE, PE, PGC) and sequencing adapters were trimmed by Cutadapt (v.1.8.1)93 with the parameters ‘-q 20,20 -m 20 --max-n 0.01 --trim-n’.

    Article Title: Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
    Article Snippet: Nature Chemical Biology Article https://doi.org/10.1038/s41589-025-01863-x Extended Data Table 2 | CCM increases alternative splicing in BMDMs Type of alternative splicing Alternative splicing (CCM vs DMSO) Basal LPS stimulated WT KO WT KO Exon skipping 59 3 43 9 Alternative 5’ splice sites 7 2 11 1 Alternative 3’ splice sites 8 1 12 0 Mutually exclusive exons 1 0 5 0 Retained introns 4 0 9 3 Note: differential splicing analysis by Novogene with RNA-seq data.

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise.
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) (62), limma (3.54.2) (63), and edgeR (3.40.2) (64, 65) packages in R (R version 4.2.2) (66) to identify genes differentially expressed between the High and Low miR-1 responders (P < 0.05).

    Article Title: Dexamethasone’s Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective
    Article Snippet: Evaluation of RNA-seq data, including group comparisons and parts of statistical analyses, was carried out by Novogene.

    Article Title: The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice.
    Article Snippet: The RNA-seq data were sequenced at the Beijing 785 Novogene company and analyzed on the servers of National Key Laboratory of Crop 786 Genetic Improvement.

    Article Title: Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.
    Article Snippet: RNA-seq data provided by Novogene (Ensembl output) were filtered using Entrez conversion in DAVID.88,89 All genes with a DE p-value <0.1 and an average count of 64 for all subjects were analyzed for Discrete Correlation Summation (DCS) Clustering.90 Enrichment analysis for the KEGG pathway database was performed using ShineyGO 0.77.91 Pathways with FDR %0.05 cutoff were explored.

    Generated:

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) , limma (3.54.2) , and edgeR (3.40.2) ( , ) packages in R (R version 4.2.2) ( ) to identify genes differentially expressed between the High and Low miR-1 responders ( P < 0.05).

    Article Title: Trimethylamine-N-oxide enhances drought tolerance in Eucalyptus by increasing photosynthesis.
    Article Snippet: Drought stress significantly reduces agricultural productivity, threatening global food security and timber production.. Although trimethylamine-N-oxide (TMAO) has been shown to enhance drought tolerance in plants such as Arabidopsis thaliana and tomato, the physiological and molecular mechanisms by which it regulates drought tolerance in plants remain unclear.. In this study, we investigated the physiological and transcriptomic changes in Eucalyptus under drought stress following exogenous TMAO treatment.

    Article Title: Improving gene isoform quantification with miniQuant.
    Article Snippet: Paired-end Illumina RNA-seq data (2 × 150 bp) were generated in Novogene company, with three replicates for each of four samples (ESC, DE, PE, PGC) and sequencing adapters were trimmed by Cutadapt (v.1.8.1)93 with the parameters ‘-q 20,20 -m 20 --max-n 0.01 --trim-n’.

    Article Title: Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
    Article Snippet: Nature Chemical Biology Article https://doi.org/10.1038/s41589-025-01863-x Extended Data Table 2 | CCM increases alternative splicing in BMDMs Type of alternative splicing Alternative splicing (CCM vs DMSO) Basal LPS stimulated WT KO WT KO Exon skipping 59 3 43 9 Alternative 5’ splice sites 7 2 11 1 Alternative 3’ splice sites 8 1 12 0 Mutually exclusive exons 1 0 5 0 Retained introns 4 0 9 3 Note: differential splicing analysis by Novogene with RNA-seq data.

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise.
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) (62), limma (3.54.2) (63), and edgeR (3.40.2) (64, 65) packages in R (R version 4.2.2) (66) to identify genes differentially expressed between the High and Low miR-1 responders (P < 0.05).

    Article Title: Dexamethasone’s Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective
    Article Snippet: Evaluation of RNA-seq data, including group comparisons and parts of statistical analyses, was carried out by Novogene.

    Article Title: The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice.
    Article Snippet: The RNA-seq data were sequenced at the Beijing 785 Novogene company and analyzed on the servers of National Key Laboratory of Crop 786 Genetic Improvement.

    Article Title: Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.
    Article Snippet: RNA-seq data provided by Novogene (Ensembl output) were filtered using Entrez conversion in DAVID.88,89 All genes with a DE p-value <0.1 and an average count of 64 for all subjects were analyzed for Discrete Correlation Summation (DCS) Clustering.90 Enrichment analysis for the KEGG pathway database was performed using ShineyGO 0.77.91 Pathways with FDR %0.05 cutoff were explored.

    Pyrolysis Gas Chromatography:

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) , limma (3.54.2) , and edgeR (3.40.2) ( , ) packages in R (R version 4.2.2) ( ) to identify genes differentially expressed between the High and Low miR-1 responders ( P < 0.05).

    Article Title: Trimethylamine-N-oxide enhances drought tolerance in Eucalyptus by increasing photosynthesis.
    Article Snippet: Drought stress significantly reduces agricultural productivity, threatening global food security and timber production.. Although trimethylamine-N-oxide (TMAO) has been shown to enhance drought tolerance in plants such as Arabidopsis thaliana and tomato, the physiological and molecular mechanisms by which it regulates drought tolerance in plants remain unclear.. In this study, we investigated the physiological and transcriptomic changes in Eucalyptus under drought stress following exogenous TMAO treatment.

    Article Title: Improving gene isoform quantification with miniQuant.
    Article Snippet: Paired-end Illumina RNA-seq data (2 × 150 bp) were generated in Novogene company, with three replicates for each of four samples (ESC, DE, PE, PGC) and sequencing adapters were trimmed by Cutadapt (v.1.8.1)93 with the parameters ‘-q 20,20 -m 20 --max-n 0.01 --trim-n’.

    Article Title: Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
    Article Snippet: Nature Chemical Biology Article https://doi.org/10.1038/s41589-025-01863-x Extended Data Table 2 | CCM increases alternative splicing in BMDMs Type of alternative splicing Alternative splicing (CCM vs DMSO) Basal LPS stimulated WT KO WT KO Exon skipping 59 3 43 9 Alternative 5’ splice sites 7 2 11 1 Alternative 3’ splice sites 8 1 12 0 Mutually exclusive exons 1 0 5 0 Retained introns 4 0 9 3 Note: differential splicing analysis by Novogene with RNA-seq data.

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise.
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) (62), limma (3.54.2) (63), and edgeR (3.40.2) (64, 65) packages in R (R version 4.2.2) (66) to identify genes differentially expressed between the High and Low miR-1 responders (P < 0.05).

    Article Title: Dexamethasone’s Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective
    Article Snippet: Evaluation of RNA-seq data, including group comparisons and parts of statistical analyses, was carried out by Novogene.

    Article Title: The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice.
    Article Snippet: The RNA-seq data were sequenced at the Beijing 785 Novogene company and analyzed on the servers of National Key Laboratory of Crop 786 Genetic Improvement.

    Article Title: Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.
    Article Snippet: RNA-seq data provided by Novogene (Ensembl output) were filtered using Entrez conversion in DAVID.88,89 All genes with a DE p-value <0.1 and an average count of 64 for all subjects were analyzed for Discrete Correlation Summation (DCS) Clustering.90 Enrichment analysis for the KEGG pathway database was performed using ShineyGO 0.77.91 Pathways with FDR %0.05 cutoff were explored.

    Sequencing:

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) , limma (3.54.2) , and edgeR (3.40.2) ( , ) packages in R (R version 4.2.2) ( ) to identify genes differentially expressed between the High and Low miR-1 responders ( P < 0.05).

    Article Title: Trimethylamine-N-oxide enhances drought tolerance in Eucalyptus by increasing photosynthesis.
    Article Snippet: Drought stress significantly reduces agricultural productivity, threatening global food security and timber production.. Although trimethylamine-N-oxide (TMAO) has been shown to enhance drought tolerance in plants such as Arabidopsis thaliana and tomato, the physiological and molecular mechanisms by which it regulates drought tolerance in plants remain unclear.. In this study, we investigated the physiological and transcriptomic changes in Eucalyptus under drought stress following exogenous TMAO treatment.

    Article Title: Improving gene isoform quantification with miniQuant.
    Article Snippet: Paired-end Illumina RNA-seq data (2 × 150 bp) were generated in Novogene company, with three replicates for each of four samples (ESC, DE, PE, PGC) and sequencing adapters were trimmed by Cutadapt (v.1.8.1)93 with the parameters ‘-q 20,20 -m 20 --max-n 0.01 --trim-n’.

    Article Title: Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
    Article Snippet: Nature Chemical Biology Article https://doi.org/10.1038/s41589-025-01863-x Extended Data Table 2 | CCM increases alternative splicing in BMDMs Type of alternative splicing Alternative splicing (CCM vs DMSO) Basal LPS stimulated WT KO WT KO Exon skipping 59 3 43 9 Alternative 5’ splice sites 7 2 11 1 Alternative 3’ splice sites 8 1 12 0 Mutually exclusive exons 1 0 5 0 Retained introns 4 0 9 3 Note: differential splicing analysis by Novogene with RNA-seq data.

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise.
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) (62), limma (3.54.2) (63), and edgeR (3.40.2) (64, 65) packages in R (R version 4.2.2) (66) to identify genes differentially expressed between the High and Low miR-1 responders (P < 0.05).

    Article Title: Dexamethasone’s Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective
    Article Snippet: Evaluation of RNA-seq data, including group comparisons and parts of statistical analyses, was carried out by Novogene.

    Article Title: The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice.
    Article Snippet: The RNA-seq data were sequenced at the Beijing 785 Novogene company and analyzed on the servers of National Key Laboratory of Crop 786 Genetic Improvement.

    Article Title: Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.
    Article Snippet: RNA-seq data provided by Novogene (Ensembl output) were filtered using Entrez conversion in DAVID.88,89 All genes with a DE p-value <0.1 and an average count of 64 for all subjects were analyzed for Discrete Correlation Summation (DCS) Clustering.90 Enrichment analysis for the KEGG pathway database was performed using ShineyGO 0.77.91 Pathways with FDR %0.05 cutoff were explored.

    Alternative Splicing:

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) , limma (3.54.2) , and edgeR (3.40.2) ( , ) packages in R (R version 4.2.2) ( ) to identify genes differentially expressed between the High and Low miR-1 responders ( P < 0.05).

    Article Title: Trimethylamine-N-oxide enhances drought tolerance in Eucalyptus by increasing photosynthesis.
    Article Snippet: Drought stress significantly reduces agricultural productivity, threatening global food security and timber production.. Although trimethylamine-N-oxide (TMAO) has been shown to enhance drought tolerance in plants such as Arabidopsis thaliana and tomato, the physiological and molecular mechanisms by which it regulates drought tolerance in plants remain unclear.. In this study, we investigated the physiological and transcriptomic changes in Eucalyptus under drought stress following exogenous TMAO treatment.

    Article Title: Improving gene isoform quantification with miniQuant.
    Article Snippet: Paired-end Illumina RNA-seq data (2 × 150 bp) were generated in Novogene company, with three replicates for each of four samples (ESC, DE, PE, PGC) and sequencing adapters were trimmed by Cutadapt (v.1.8.1)93 with the parameters ‘-q 20,20 -m 20 --max-n 0.01 --trim-n’.

    Article Title: Pharmacological targeting of BMAL1 modulates circadian and immune pathways.
    Article Snippet: Nature Chemical Biology Article https://doi.org/10.1038/s41589-025-01863-x Extended Data Table 2 | CCM increases alternative splicing in BMDMs Type of alternative splicing Alternative splicing (CCM vs DMSO) Basal LPS stimulated WT KO WT KO Exon skipping 59 3 43 9 Alternative 5’ splice sites 7 2 11 1 Alternative 3’ splice sites 8 1 12 0 Mutually exclusive exons 1 0 5 0 Retained introns 4 0 9 3 Note: differential splicing analysis by Novogene with RNA-seq data.

    Article Title: Extracellular vesicle transfer of miR-1 to adipose tissue modifies lipolytic pathways following resistance exercise.
    Article Snippet: Downstream analyses of RNA-Seq data generated by Novogene were completed using tidyverse (version 2.0.0) (62), limma (3.54.2) (63), and edgeR (3.40.2) (64, 65) packages in R (R version 4.2.2) (66) to identify genes differentially expressed between the High and Low miR-1 responders (P < 0.05).

    Article Title: Dexamethasone’s Clinical Efficacy in Experimental Autoimmune Pancreatitis Correlates with a Unique Transcriptomic Signature, Whilst Kinase Inhibitors Are Not Effective
    Article Snippet: Evaluation of RNA-seq data, including group comparisons and parts of statistical analyses, was carried out by Novogene.

    Article Title: The OsSRO1c-OsDREB2B complex undergoes protein phase transition to enhance cold tolerance in rice.
    Article Snippet: The RNA-seq data were sequenced at the Beijing 785 Novogene company and analyzed on the servers of National Key Laboratory of Crop 786 Genetic Improvement.

    Article Title: Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk.
    Article Snippet: RNA-seq data provided by Novogene (Ensembl output) were filtered using Entrez conversion in DAVID.88,89 All genes with a DE p-value <0.1 and an average count of 64 for all subjects were analyzed for Discrete Correlation Summation (DCS) Clustering.90 Enrichment analysis for the KEGG pathway database was performed using ShineyGO 0.77.91 Pathways with FDR %0.05 cutoff were explored.



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    bulk rna sequencing rna seq data  (Biotechnology Information)
    86
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    Increased IFITM and decreased DHODH expression characterize the placenta in the context of HDPs (A) Volcano plot of transcriptomic changes identified by <t>RNA-seq.</t> Transcripts highlighted in red or blue were significantly altered ( q value < 0.05). (B) Differentially expressed genes were classified by functional enrichment analysis using the Reactome pathway database and Gene Ontology (GO) biological processes or cellular components. (C) Heatmap of mitochondria-related genes downregulated in the placenta in the context of HDPs. Genes with higher expression are shown in green, and those with lower expression are shown in red. Ctrl: premature delivery, n = 5; HDP, n = 5. (D) Expression of DHODH, OPA1, DNM1L, MFN1, TFAM, and IFITM1-3 in trophoblast BeWo cells treated with forskolin (FSK, 2.5 μM) and rotenone (Rote, 50 nM) for 48 h. GAPDH was used as a reference gene. The data are presented as the mean ± SEM from three independent experiments. ∗ p < 0.05, ∗∗ p < 0.01 vs. FSK alone (Tukey’s test). (E) Expression of IFITMs in BeWo cells treated with FSK (2.5 μM), orludodstat (Orlu, 1 nM), or brequinar (Bre, 25 nM) for 48 h. GAPDH was used as a reference gene. The data are presented as the mean ± SEM from three independent experiments. ∗∗ p < 0.01 vs. Ctrl; † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. FSK alone (Tukey’s test).
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    A , scRNA-seq UMAP of d35 CN colored by assigned cell type, excitatory (EXC) and inhibitory (INH) neuronal subtypes, glioblasts, and unassigned cells. The numbers of cells per cluster are shown in parentheses. B, Violin plots of Seurat-normalized expression levels for cell-identity marker genes. C, UMAPs of d35 CNs exposed to different treatments (DMSO = blue; dTAG = red). D, DEGs per cell type after ES→CN depletion, as identified with Seurat FindMarkers (padj < 0.05, |log2FoldChange| > 0.5). E, Degree of similarity of combined DEGs identified in the indicated neuronal cell types, as indicated by log2FoldChange pairwise Pearson correlation. F, Functional enrichment (gProfiler; padj < 0.05) for ranked DEGs in the indicated neuronal subtypes. G, Violin plots showing subtype-specific (left) and shared (right) DEGs between neuronal subtypes. Upregulated DEGs highlighted in red and downregulated DEGs highlighted in blue. H, Impact of EHMT1 depletion on the neuronal maturation score in neuronal subtypes (see Methods). Mann-Whitney test with Bonferroni correction. I, As H for neuronal function score (see Methods). J, Transcription factors with regulons significantly affected by EHMT1 depletion (Mann-Whitney test with Bonferroni correction), as determined by SCENIC (see Methods). (+)(-) indicate positive and negative correlations between the expression of a transcription factor and its regulon, respectively. Arrows indicate significant (padj<0.05) log2FC (dTAG/DMSO) of the TF in the cell type.

    Journal: bioRxiv

    Article Title: Developmental rewiring of EHMT1 function during human cortical neurogenesis

    doi: 10.64898/2026.10.09.757098

    Figure Lengend Snippet: A , scRNA-seq UMAP of d35 CN colored by assigned cell type, excitatory (EXC) and inhibitory (INH) neuronal subtypes, glioblasts, and unassigned cells. The numbers of cells per cluster are shown in parentheses. B, Violin plots of Seurat-normalized expression levels for cell-identity marker genes. C, UMAPs of d35 CNs exposed to different treatments (DMSO = blue; dTAG = red). D, DEGs per cell type after ES→CN depletion, as identified with Seurat FindMarkers (padj < 0.05, |log2FoldChange| > 0.5). E, Degree of similarity of combined DEGs identified in the indicated neuronal cell types, as indicated by log2FoldChange pairwise Pearson correlation. F, Functional enrichment (gProfiler; padj < 0.05) for ranked DEGs in the indicated neuronal subtypes. G, Violin plots showing subtype-specific (left) and shared (right) DEGs between neuronal subtypes. Upregulated DEGs highlighted in red and downregulated DEGs highlighted in blue. H, Impact of EHMT1 depletion on the neuronal maturation score in neuronal subtypes (see Methods). Mann-Whitney test with Bonferroni correction. I, As H for neuronal function score (see Methods). J, Transcription factors with regulons significantly affected by EHMT1 depletion (Mann-Whitney test with Bonferroni correction), as determined by SCENIC (see Methods). (+)(-) indicate positive and negative correlations between the expression of a transcription factor and its regulon, respectively. Arrows indicate significant (padj<0.05) log2FC (dTAG/DMSO) of the TF in the cell type.

    Article Snippet: We conducted bioinformatic analysis of bulk RNA-seq data for d35 CN single-cell RNA-seq validation using Plasmidsaurus’s workflow.

    Techniques: Expressing, Marker, Functional Assay, MANN-WHITNEY

    Increased IFITM and decreased DHODH expression characterize the placenta in the context of HDPs (A) Volcano plot of transcriptomic changes identified by RNA-seq. Transcripts highlighted in red or blue were significantly altered ( q value < 0.05). (B) Differentially expressed genes were classified by functional enrichment analysis using the Reactome pathway database and Gene Ontology (GO) biological processes or cellular components. (C) Heatmap of mitochondria-related genes downregulated in the placenta in the context of HDPs. Genes with higher expression are shown in green, and those with lower expression are shown in red. Ctrl: premature delivery, n = 5; HDP, n = 5. (D) Expression of DHODH, OPA1, DNM1L, MFN1, TFAM, and IFITM1-3 in trophoblast BeWo cells treated with forskolin (FSK, 2.5 μM) and rotenone (Rote, 50 nM) for 48 h. GAPDH was used as a reference gene. The data are presented as the mean ± SEM from three independent experiments. ∗ p < 0.05, ∗∗ p < 0.01 vs. FSK alone (Tukey’s test). (E) Expression of IFITMs in BeWo cells treated with FSK (2.5 μM), orludodstat (Orlu, 1 nM), or brequinar (Bre, 25 nM) for 48 h. GAPDH was used as a reference gene. The data are presented as the mean ± SEM from three independent experiments. ∗∗ p < 0.01 vs. Ctrl; † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. FSK alone (Tukey’s test).

    Journal: iScience

    Article Title: DHODH regulates trophoblast fusion via IFITM-reduced plasma membrane fluidity: Implications for hypertensive disorders of pregnancy

    doi: 10.1016/j.isci.2026.116163

    Figure Lengend Snippet: Increased IFITM and decreased DHODH expression characterize the placenta in the context of HDPs (A) Volcano plot of transcriptomic changes identified by RNA-seq. Transcripts highlighted in red or blue were significantly altered ( q value < 0.05). (B) Differentially expressed genes were classified by functional enrichment analysis using the Reactome pathway database and Gene Ontology (GO) biological processes or cellular components. (C) Heatmap of mitochondria-related genes downregulated in the placenta in the context of HDPs. Genes with higher expression are shown in green, and those with lower expression are shown in red. Ctrl: premature delivery, n = 5; HDP, n = 5. (D) Expression of DHODH, OPA1, DNM1L, MFN1, TFAM, and IFITM1-3 in trophoblast BeWo cells treated with forskolin (FSK, 2.5 μM) and rotenone (Rote, 50 nM) for 48 h. GAPDH was used as a reference gene. The data are presented as the mean ± SEM from three independent experiments. ∗ p < 0.05, ∗∗ p < 0.01 vs. FSK alone (Tukey’s test). (E) Expression of IFITMs in BeWo cells treated with FSK (2.5 μM), orludodstat (Orlu, 1 nM), or brequinar (Bre, 25 nM) for 48 h. GAPDH was used as a reference gene. The data are presented as the mean ± SEM from three independent experiments. ∗∗ p < 0.01 vs. Ctrl; † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. FSK alone (Tukey’s test).

    Article Snippet: • Raw RNA-seq data derived from human placental samples and trophoblast cell lines have been deposited at the DNA DataBank of Japan (DDBJ) Sequence Read Archive as DDBJ: DRA021720 and DRA021721 and are publicly available as of the date of publication.

    Techniques: Expressing, RNA Sequencing, Functional Assay

    DHODH regulates IFITM expression via IRF1 (A–H) BeWo cells or DHODH-KD BeWo cells were treated with FSK (2.5 μM), Orlu (1 nM), or Bre (25 nM) for 48 h. (A) Volcano plot showing transcriptomic changes identified by RNA-seq. Transcripts highlighted in red or blue were considered differentially expressed, as indicated by an expression change ≥2-fold ( p < 0.05). (B) Correlation analysis of RNA-seq data from Orlu-, Bre-treated, and DHODH-KD cells. (C) Differentially expressed genes were classified by functional enrichment analysis using the Wiki pathway database and GO biological processes or cellular components. (D) RNA-seq was used to evaluate the expression levels of genes associated with syncytialization. (E) RNA-seq was used to evaluate the expression levels of IRF family genes. (F) Immunoblotting for IRF1, total IRF3, and p -IRF3. GAPDH was used as a loading control. Representative data from three independent experiments are shown. The graph shows the total IRF3 and p -IRF3 levels normalized to GAPDH levels from three independent experiments. ∗∗ p < 0.01, ∗∗∗ p < 0.001 vs. Ctrl (Tukey’s test). Values represent the mean ± SEM. (G) ChIP assay showing IRF1 binding to upstream regulatory regions (up to 3 kbp) of the IFITM1, IFITM2, and IFITM3 loci in BeWo cells treated with FSK alone (2.5 μM) for 48 h. ∗ p < 0.05 vs. Ctrl; † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. FSK alone (Tukey’s test). (H) Immunofluorescence staining of IRF1 (red). Nuclei were counterstained with DAPI (blue). Scale bars, 5 μm. The graph shows the number of staining cells from three independent experiments. Values represent the mean ± SEM. ∗∗∗ p < 0.001 vs. FSK.

    Journal: iScience

    Article Title: DHODH regulates trophoblast fusion via IFITM-reduced plasma membrane fluidity: Implications for hypertensive disorders of pregnancy

    doi: 10.1016/j.isci.2026.116163

    Figure Lengend Snippet: DHODH regulates IFITM expression via IRF1 (A–H) BeWo cells or DHODH-KD BeWo cells were treated with FSK (2.5 μM), Orlu (1 nM), or Bre (25 nM) for 48 h. (A) Volcano plot showing transcriptomic changes identified by RNA-seq. Transcripts highlighted in red or blue were considered differentially expressed, as indicated by an expression change ≥2-fold ( p < 0.05). (B) Correlation analysis of RNA-seq data from Orlu-, Bre-treated, and DHODH-KD cells. (C) Differentially expressed genes were classified by functional enrichment analysis using the Wiki pathway database and GO biological processes or cellular components. (D) RNA-seq was used to evaluate the expression levels of genes associated with syncytialization. (E) RNA-seq was used to evaluate the expression levels of IRF family genes. (F) Immunoblotting for IRF1, total IRF3, and p -IRF3. GAPDH was used as a loading control. Representative data from three independent experiments are shown. The graph shows the total IRF3 and p -IRF3 levels normalized to GAPDH levels from three independent experiments. ∗∗ p < 0.01, ∗∗∗ p < 0.001 vs. Ctrl (Tukey’s test). Values represent the mean ± SEM. (G) ChIP assay showing IRF1 binding to upstream regulatory regions (up to 3 kbp) of the IFITM1, IFITM2, and IFITM3 loci in BeWo cells treated with FSK alone (2.5 μM) for 48 h. ∗ p < 0.05 vs. Ctrl; † p < 0.05, †† p < 0.01, ††† p < 0.001 vs. FSK alone (Tukey’s test). (H) Immunofluorescence staining of IRF1 (red). Nuclei were counterstained with DAPI (blue). Scale bars, 5 μm. The graph shows the number of staining cells from three independent experiments. Values represent the mean ± SEM. ∗∗∗ p < 0.001 vs. FSK.

    Article Snippet: • Raw RNA-seq data derived from human placental samples and trophoblast cell lines have been deposited at the DNA DataBank of Japan (DDBJ) Sequence Read Archive as DDBJ: DRA021720 and DRA021721 and are publicly available as of the date of publication.

    Techniques: Expressing, RNA Sequencing, Functional Assay, Western Blot, Control, Binding Assay, Immunofluorescence, Staining